α-Amination of keto-nitrones via Multihetero-Cope rearrangement employing an imidoyl chloride reagent
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چکیده
منابع مشابه
α-Amination of keto-nitrones via multihetero-Cope rearrangement employing an imidoyl chloride reagent.
α-Aminations of ketone-derived nitrones have been developed via [3,3]-rearrangement of the intermediates generated upon condensation with imidoyl chlorides. Careful reagent selection provides synthetically attractive amino protecting groups. The enediamide or α'-carbamoyl enamide products can be hydrolyzed to the desired carbonyl, or exposed to electrophiles for further α-functionalization.
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2012
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c2cc33401a